Ku Autoantigen

"Ku Autoantigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that functions with DNA LIGASE IV in the repair of DOUBLE-STRANDED DNA BREAKS and V(D)J RECOMBINATION.

Descriptor ID	D000072200
MeSH Number(s)	D08.811.277.040.025.159.155 D08.811.399.340.155 D12.776.157.687.493 D12.776.260.525 D12.776.660.625.625 D12.776.660.720.493 D23.050.290.625
Concept/Terms	Ku Autoantigen Ku Autoantigen Autoantigen, Ku Ku Heterodimer Heterodimer, Ku Ku Protein Ku Antigen Antigen, Ku G22P1 Antigen Antigen, G22P1 Ku80 Antigen Ku80 Antigen Antigen, Ku80 Ku Autoantigen, 80 kDa XRCC5 Protein X-ray Repair Cross-Complementing Protein 5 X ray Repair Cross Complementing Protein 5 Ku70 Antigen Ku70 Antigen Antigen, Ku70 Ku Autoantigen, 70 kDa XRCC6 Protein X-ray Repair Cross-Complementing Protein 6 X ray Repair Cross Complementing Protein 6

Below are MeSH descriptors whose meaning is more general than "Ku Autoantigen".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Acid Anhydride Hydrolases [D08.811.277.040]
Adenosine Triphosphatases [D08.811.277.040.025]
DNA Helicases [D08.811.277.040.025.159]
Ku Autoantigen [D08.811.277.040.025.159.155]
Isomerases [D08.811.399]
DNA Helicases [D08.811.399.340]
Ku Autoantigen [D08.811.399.340.155]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
Ku Autoantigen [D12.776.157.687.493]
DNA-Binding Proteins [D12.776.260]
Ku Autoantigen [D12.776.260.525]
Nuclear Proteins [D12.776.660]
Antigens, Nuclear [D12.776.660.625]
Ku Autoantigen [D12.776.660.625.625]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
Ku Autoantigen [D12.776.660.720.493]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Nuclear [D23.050.290]
Ku Autoantigen [D23.050.290.625]

Below are MeSH descriptors whose meaning is related to "Ku Autoantigen".

Below are MeSH descriptors whose meaning is more specific than "Ku Autoantigen".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ku Autoantigen" by people in this website by year, and whether "Ku Autoantigen" was a major or minor topic of these publications.

Bar chart showing 8 publications over 8 distinct years, with a maximum of 1 publications in 1997 and 1999 and 2004 and 2005 and 2006 and 2013 and 2014 and 2016

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1997	1	1
1999	1	1
2004	1	1
2005	1	1
2006	1	1
2013	1	1
2014	1	1
2016	1	1

Below are the most recent publications written about "Ku Autoantigen" by people in Profiles.

Patidar PL, Motea EA, Fattah FJ, Zhou Y, Morales JC, Xie Y, Garner HR, Boothman DA. The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair. Nucleic Acids Res. 2016 Feb 29; 44(4):1718-31.

View in: PubMed
Maiti AK, Kim-Howard X, Motghare P, Pradhan V, Chua KH, Sun C, Arango-Guerrero MT, Ghosh K, Niewold TB, Harley JB, Anaya JM, Looger LL, Nath SK. Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM. Hum Mol Genet. 2014 Aug 01; 23(15):4161-76.

View in: PubMed
Molineros JE, Maiti AK, Sun C, Looger LL, Han S, Kim-Howard X, Glenn S, Adler A, Kelly JA, Niewold TB, Gilkeson GS, Brown EE, Alarcón GS, Edberg JC, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Freedman BI, Tsao BP, Criswell LA, Jacob CO, Moore JH, Vyse TJ, Langefeld CL, Guthridge JM, Gaffney PM, Moser KL, Scofield RH, Alarcón-Riquelme ME, Williams SM, Merrill JT, James JA, Kaufman KM, Kimberly RP, Harley JB, Nath SK. Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet. 2013; 9(2):e1003222.

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Munshi A, Tanaka T, Hobbs ML, Tucker SL, Richon VM, Meyn RE. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther. 2006 Aug; 5(8):1967-74.

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Munshi A, Kurland JF, Nishikawa T, Tanaka T, Hobbs ML, Tucker SL, Ismail S, Stevens C, Meyn RE. Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. Clin Cancer Res. 2005 Jul 01; 11(13):4912-22.

View in: PubMed
Byrum J, Jordan S, Safrany ST, Rodgers W. Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobility. Nucleic Acids Res. 2004; 32(9):2776-84.

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Hannan RD, Cavanaugh A, Hempel WM, Moss T, Rothblum L. Identification of a mammalian RNA polymerase I holoenzyme containing components of the DNA repair/replication system. Nucleic Acids Res. 1999 Sep 15; 27(18):3720-7.

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Hausmanowa-Petrusewicz I, Kowalska-Oledzka E, Miller FW, Jarzabek-Chorzelska M, Targoff IN, Blaszczyk-Kostanecka M, Jablonska S. Clinical, serologic, and immunogenetic features in Polish patients with idiopathic inflammatory myopathies. Arthritis Rheum. 1997 Jul; 40(7):1257-66.

View in: PubMed

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