"CRISPR-Cas Systems" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Adaptive antiviral defense mechanisms, in archaea and bacteria, based on DNA repeat arrays called CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS (CRISPR elements) that function in conjunction with CRISPR-ASSOCIATED PROTEINS (Cas proteins). Several types have been distinguished, including Type I, Type II, and Type III, based on signature motifs of CRISPR-ASSOCIATED PROTEINS.
| Descriptor ID |
D064113
|
| MeSH Number(s) |
G05.308.203.374.394
|
| Concept/Terms |
CRISPR-Cas Systems- CRISPR-Cas Systems
- CRISPR Cas Systems
- CRISPR-Cas System
- System, CRISPR-Cas
- Systems, CRISPR-Cas
|
Below are MeSH descriptors whose meaning is more general than "CRISPR-Cas Systems".
Below are MeSH descriptors whose meaning is more specific than "CRISPR-Cas Systems".
This graph shows the total number of publications written about "CRISPR-Cas Systems" by people in this website by year, and whether "CRISPR-Cas Systems" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2015 | 4 | 0 | 4 |
| 2016 | 1 | 0 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 2 | 3 |
| 2019 | 2 | 5 | 7 |
| 2020 | 2 | 2 | 4 |
| 2021 | 3 | 3 | 6 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 2 | 1 | 3 |
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Below are the most recent publications written about "CRISPR-Cas Systems" by people in Profiles.
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In Situ Complexation of sgRNA and Cas12a Improves the Performance of a One-Pot RPA-CRISPR-Cas12 Assay. Anal Chem. 2024 06 25; 96(25):10443-10450.
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Validation of human telomere length multi-ancestry meta-analysis association signals identifies POP5 and KBTBD6 as human telomere length regulation genes. Nat Commun. 2024 May 24; 15(1):4417.
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Unity among the diverse RNA-guided CRISPR-Cas interference mechanisms. J Biol Chem. 2024 Jun; 300(6):107295.
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Differential Divalent Metal Binding by SpyCas9's RuvC Active Site Contributes to Nonspecific DNA Cleavage. CRISPR J. 2023 Dec; 6(6):527-542.
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Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects. CRISPR J. 2022 04; 5(2):329-340.
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Steroid-sensitive nephrotic syndrome candidate gene CLVS1 regulates podocyte oxidative stress and endocytosis. JCI Insight. 2022 01 25; 7(2).
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Cas9 Nickase-Based Genome Editing in Clostridium cellulolyticum. Methods Mol Biol. 2022; 2479:227-243.
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Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration. FASEB J. 2021 12; 35(12):e22058.
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Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence. Biochemistry. 2021 12 14; 60(49):3783-3800.
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Deficiencies in the DNA Binding Protein ARID3a Alter Chromatin Structures Important for Early Human Erythropoiesis. Immunohorizons. 2021 10 18; 5(10):802-817.