"RNA, Guide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small kinetoplastid mitochondrial RNA that plays a major role in RNA EDITING. These molecules form perfect hybrids with edited mRNA sequences and possess nucleotide sequences at their 5'-ends that are complementary to the sequences of the mRNA's immediately downstream of the pre-edited regions.
| Descriptor ID |
D017394
|
| MeSH Number(s) |
D13.444.735.790.552.625
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "RNA, Guide".
Below are MeSH descriptors whose meaning is more specific than "RNA, Guide".
This graph shows the total number of publications written about "RNA, Guide" by people in this website by year, and whether "RNA, Guide" was a major or minor topic of these publications.
To see the data from this visualization as text,
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 2 | 1 | 3 |
| 2021 | 2 | 0 | 2 |
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Below are the most recent publications written about "RNA, Guide" by people in Profiles.
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Cas9 Nickase-Based Genome Editing in Clostridium cellulolyticum. Methods Mol Biol. 2022; 2479:227-243.
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Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence. Biochemistry. 2021 12 14; 60(49):3783-3800.
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The bridge helix of Cas12a imparts selectivity in cis-DNA cleavage and regulates trans-DNA cleavage. FEBS Lett. 2021 04; 595(7):892-912.
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Conditional depletion of the RNA polymerase I subunit PAF53 reveals that it is essential for mitosis and enables identification of functional domains. J Biol Chem. 2019 12 27; 294(52):19907-19922.
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Structural and functional insights into the bona fide catalytic state of Streptococcus pyogenes Cas9 HNH nuclease domain. Elife. 2019 07 30; 8.
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Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance. Biochemistry. 2019 04 09; 58(14):1905-1917.
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Switchable genome editing via genetic code expansion. Sci Rep. 2018 07 03; 8(1):10051.
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The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit. Mol Cell. 2017 Oct 05; 68(1):15-25.
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Nucleic Acid-Dependent Conformational Changes in CRISPR-Cas9 Revealed by Site-Directed Spin Labeling. Cell Biochem Biophys. 2017 Jun; 75(2):203-210.
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REH2C Helicase and GRBC Subcomplexes May Base Pair through mRNA and Small Guide RNA in Kinetoplastid Editosomes. J Biol Chem. 2016 Mar 11; 291(11):5753-5764.