Steroid 17-alpha-Hydroxylase
"Steroid 17-alpha-Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.
| Descriptor ID |
D013254
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| MeSH Number(s) |
D08.244.453.487.500 D08.244.453.915.748 D08.811.682.690.708.170.444.500 D08.811.682.690.708.170.915.748 D12.776.422.220.453.487.500 D12.776.422.220.453.915.748
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| Concept/Terms |
Steroid 17-alpha-Hydroxylase- Steroid 17-alpha-Hydroxylase
- 17-alpha-Hydroxylase, Steroid
- Steroid 17 alpha-Hydroxylase
- 17 alpha-Hydroxylase, Steroid
- Steroid 17 alpha Hydroxylase
- Steroid-17-Hydroxylase
- Steroid 17 Hydroxylase
- Steroid 17-Hydroxylase
- 17-Hydroxylase, Steroid
- Steroid 17-Monooxygenase
- 17-Monooxygenase, Steroid
- Steroid 17 Monooxygenase
- 17,20-Desmolase
- 17,20 Desmolase
- 17,20-Lyase
- 17,20 Lyase
- Cytochrome P450(17 alpha)
- Steroid 17 alpha-Monooxygenase
- 17 alpha-Monooxygenase, Steroid
- Steroid 17 alpha Monooxygenase
- alpha-Monooxygenase, Steroid 17
- CYP17
- 17 alpha-Hydroxylase
- 17 alpha Hydroxylase
- P450(c17)
- Cytochrome P-450(17-alpha)
- 17 alpha-Hydroxylase Cytochrome P-450
- 17 alpha Hydroxylase Cytochrome P 450
- Cytochrome P-450(17 alpha)
17 alpha-Hydroxyprogesterone Aldolase- 17 alpha-Hydroxyprogesterone Aldolase
- 17 alpha Hydroxyprogesterone Aldolase
- Aldolase, 17 alpha-Hydroxyprogesterone
- alpha-Hydroxyprogesterone Aldolase, 17
- Hydroxyprogesterone Aldolase
- Aldolase, Hydroxyprogesterone
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Below are MeSH descriptors whose meaning is more general than "Steroid 17-alpha-Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Steroid 17-alpha-Hydroxylase".
This graph shows the total number of publications written about "Steroid 17-alpha-Hydroxylase" by people in this website by year, and whether "Steroid 17-alpha-Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Steroid 17-alpha-Hydroxylase" by people in Profiles.
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CYP17 polymorphism (rs743572) is associated with increased risk of gallbladder cancer in tobacco users. Tumour Biol. 2014 Jul; 35(7):6531-7.
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Long-term hypoxia increases endothelial nitric oxide synthase expression in the ovine fetal adrenal. Reprod Sci. 2009 Sep; 16(9):865-74.
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Role of adiponectin in regulating ovarian theca and granulosa cell function. Mol Cell Endocrinol. 2008 Mar 12; 284(1-2):38-45.
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Growth differentiation factor 9 (GDF9) stimulates proliferation and inhibits steroidogenesis by bovine theca cells: influence of follicle size on responses to GDF9. Biol Reprod. 2008 Feb; 78(2):243-53.
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Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol. 2005 Dec; 289(6):R1707-14.
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Inter- and intrafamilial variability in premature pubarche and polycystic ovary syndrome. Fertil Steril. 2002 Sep; 78(3):473-8.