Cholesterol Side-Chain Cleavage Enzyme
"Cholesterol Side-Chain Cleavage Enzyme" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
| Descriptor ID |
D002786
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| MeSH Number(s) |
D08.244.453.484.250 D08.244.453.915.212 D08.811.682.690.708.170.425.250 D08.811.682.690.708.170.915.212 D12.776.422.220.453.484.250 D12.776.422.220.453.915.212
|
| Concept/Terms |
Cholesterol Side-Chain Cleavage Enzyme- Cholesterol Side-Chain Cleavage Enzyme
- Cholesterol Side Chain Cleavage Enzyme
- Cholesterol Desmolase
- Cytochrome P-450(scc)
- CYP11A1
- CYP 11A1
- Cytochrome P450 11A1
- Cytochrome P-450 CYP11A1
- Cytochrome P 450 CYP11A1
- Cholesterol Monooxygenase (Side-Chain-Cleaving)
- 20,22-Desmolase
- 20,22 Desmolase
- Cytochrome P450scc
|
Below are MeSH descriptors whose meaning is more general than "Cholesterol Side-Chain Cleavage Enzyme".
Below are MeSH descriptors whose meaning is more specific than "Cholesterol Side-Chain Cleavage Enzyme".
This graph shows the total number of publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in this website by year, and whether "Cholesterol Side-Chain Cleavage Enzyme" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cholesterol Side-Chain Cleavage Enzyme" by people in Profiles.
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Effect of melatonin on bovine theca cells in vitro. Reprod Fertil Dev. 2018 Mar; 30(4):643-650.
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In vitro effects of the Fusarium mycotoxins fumonisin B1 and beauvericin on bovine granulosa cell proliferation and steroid production. Toxicon. 2017 Mar 15; 128:38-45.
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Effects of fumonisin B1 alone and combined with deoxynivalenol or zearalenone on porcine granulosa cell proliferation and steroid production. Theriogenology. 2014 May; 81(8):1042-9.
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Effects of fibroblast growth factor 9 (FGF9) on steroidogenesis and gene expression and control of FGF9 mRNA in bovine granulosa cells. Endocrinology. 2012 Sep; 153(9):4491-501.
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Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors. Am J Physiol Endocrinol Metab. 2008 Aug; 295(2):E446-55.
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Role of adiponectin in regulating ovarian theca and granulosa cell function. Mol Cell Endocrinol. 2008 Mar 12; 284(1-2):38-45.
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Effects of Fusarium mycotoxins on steroid production by porcine granulosa cells. Anim Reprod Sci. 2008 Aug; 107(1-2):115-30.
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Long-term hypoxia represses the expression of key genes regulating cortisol biosynthesis in the near-term ovine fetus. Am J Physiol Regul Integr Comp Physiol. 2005 Dec; 289(6):R1707-14.
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Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis. J Endocrinol. 1996 Dec; 151(3):365-73.
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2-hydroxyestradiol enhanced progesterone production by porcine granulosa cells: dependence on de novo cholesterol synthesis and stimulation of cholesterol side-chain cleavage activity and cytochrome P450scc messenger ribonucleic acid levels. Endocrinology. 1990 Dec; 127(6):2763-70.