Cyclic Nucleotide Phosphodiesterases, Type 6
"Cyclic Nucleotide Phosphodiesterases, Type 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme.
| Descriptor ID |
D054707
|
| MeSH Number(s) |
D08.811.277.352.640.150.600 D08.811.277.352.640.155.750 D12.644.360.008.600 D12.644.360.009.750 D12.776.476.008.600 D12.776.476.009.750
|
| Concept/Terms |
Cyclic Nucleotide Phosphodiesterases, Type 6- Cyclic Nucleotide Phosphodiesterases, Type 6
- Phosphodiesterase 6
- PDE6 Phosphodiesterases
- Phosphodiesterases, PDE6
- Retinal Phosphodiesterase 6
- Phosphodiesterase 6, Retinal
- Phosphodiesterase Type 6
|
Below are MeSH descriptors whose meaning is more general than "Cyclic Nucleotide Phosphodiesterases, Type 6".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Hydrolases [D08.811.277]
- Esterases [D08.811.277.352]
- Phosphoric Diester Hydrolases [D08.811.277.352.640]
- 3',5'-Cyclic-AMP Phosphodiesterases [D08.811.277.352.640.150]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.150.600]
- 3',5'-Cyclic-GMP Phosphodiesterases [D08.811.277.352.640.155]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D08.811.277.352.640.155.750]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Intracellular Signaling Peptides and Proteins [D12.644.360]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.644.360.008]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D12.644.360.008.600]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.644.360.009]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D12.644.360.009.750]
- Proteins [D12.776]
- Intracellular Signaling Peptides and Proteins [D12.776.476]
- 3',5'-Cyclic-AMP Phosphodiesterases [D12.776.476.008]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D12.776.476.008.600]
- 3',5'-Cyclic-GMP Phosphodiesterases [D12.776.476.009]
- Cyclic Nucleotide Phosphodiesterases, Type 6 [D12.776.476.009.750]
Below are MeSH descriptors whose meaning is more specific than "Cyclic Nucleotide Phosphodiesterases, Type 6".
This graph shows the total number of publications written about "Cyclic Nucleotide Phosphodiesterases, Type 6" by people in this website by year, and whether "Cyclic Nucleotide Phosphodiesterases, Type 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cyclic Nucleotide Phosphodiesterases, Type 6" by people in Profiles.
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Metabolic and Non-metabolic Roles of Pyruvate Kinase M2 Isoform in Diabetic Retinopathy. Sci Rep. 2020 05 04; 10(1):7456.
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Pyruvate kinase M2 regulates photoreceptor structure, function, and viability. Cell Death Dis. 2018 02 14; 9(2):240.
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Modulation of mouse rod photoreceptor responses by Grb14 protein. J Biol Chem. 2014 Jan 03; 289(1):358-64.
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Developmental time course distinguishes changes in spontaneous and light-evoked retinal ganglion cell activity in rd1 and rd10 mice. J Neurophysiol. 2011 Jun; 105(6):3002-9.
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Progression of neuronal and synaptic remodeling in the rd10 mouse model of retinitis pigmentosa. J Comp Neurol. 2010 Jun 01; 518(11):2071-89.