Proto-Oncogene Proteins c-kit

"Proto-Oncogene Proteins c-kit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.

Descriptor ID	D019009
MeSH Number(s)	D08.811.913.696.620.682.725.400.050 D12.776.543.750.630.124 D12.776.543.750.705.852.150.100 D12.776.543.750.750.400.200.170 D12.776.624.664.700.183
Concept/Terms	Proto-Oncogene Proteins c-kit Proto-Oncogene Proteins c-kit Proto Oncogene Proteins c kit c-kit, Proto-Oncogene Proteins Stem Cell Factor Receptor SCF Receptor p145 c-kit c-kit, p145 p145 c kit p145(c-kit) p145c-kit p145c kit CD117 Antigen Antigens, CD117 CD117 Antigens Proto-Oncogene Protein c-kit Proto Oncogene Protein c kit c-kit, Proto-Oncogene Protein c-kit Protein c kit Protein kit Proto-Oncogene Protein Proto-Oncogene Protein, kit kit Proto Oncogene Protein Receptor, Stem Cell Factor Proto-Oncogene Protein kit Proto Oncogene Protein kit c-kit Receptor c kit Receptor

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-kit".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
Proto-Oncogene Proteins c-kit [D08.811.913.696.620.682.725.400.050]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Membrane Proteins [D12.776.543]
Receptors, Cell Surface [D12.776.543.750]
Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
Proto-Oncogene Proteins c-kit [D12.776.543.750.630.124]
Receptors, Immunologic [D12.776.543.750.705]
Receptors, Cytokine [D12.776.543.750.705.852]
Receptors, Colony-Stimulating Factor [D12.776.543.750.705.852.150]
Proto-Oncogene Proteins c-kit [D12.776.543.750.705.852.150.100]
Receptors, Peptide [D12.776.543.750.750]
Receptors, Growth Factor [D12.776.543.750.750.400]
Receptors, Colony-Stimulating Factor [D12.776.543.750.750.400.200]
Proto-Oncogene Proteins c-kit [D12.776.543.750.750.400.200.170]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
Proto-Oncogene Proteins c-kit [D12.776.624.664.700.183]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins c-kit".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-kit".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins c-kit" by people in this website by year, and whether "Proto-Oncogene Proteins c-kit" was a major or minor topic of these publications.

Bar chart showing 6 publications over 6 distinct years, with a maximum of 1 publications in 1998 and 2009 and 2010 and 2012 and 2013 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	1	0	1
2009	0	1	1
2010	0	1	1
2012	0	1	1
2013	1	0	1
2015	0	1	1

Below are the most recent publications written about "Proto-Oncogene Proteins c-kit" by people in Profiles.

Gandhapudi SK, Tan C, Marino JH, Taylor AA, Pack CC, Gaikwad J, Van De Wiele CJ, Wren JD, Teague TK. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol. 2015 Apr 15; 194(8):3820-8.

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Wetterskog D, Wilkerson PM, Rodrigues DN, Lambros MB, Fritchie K, Andersson MK, Natrajan R, Gauthier A, Di Palma S, Shousha S, Gatalica Z, Töpfer C, Vukovic V, A'Hern R, Weigelt B, Vincent-Salomon A, Stenman G, Rubin BP, Reis-Filho JS. Mutation profiling of adenoid cystic carcinomas from multiple anatomical sites identifies mutations in the RAS pathway, but no KIT mutations. Histopathology. 2013 Mar; 62(4):543-50.

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Kuroda N, Maris S, Monzon FA, Tan PH, Thomas A, Petersson FB, Gatalica Z, Ghazalpour A, Bender RP, Grossmann P, Michal M, Svajdler M, Ovcak Z, Hora M, Hes O. Juxtaglomerular cell tumor: a morphological, immunohistochemical and genetic study of six cases. Hum Pathol. 2013 Jan; 44(1):47-54.

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Petersson F, Gatalica Z, Grossmann P, Perez Montiel MD, Alvarado Cabrero I, Bulimbasic S, Swatek A, Straka L, Tichy T, Hora M, Kuroda N, Legendre B, Michal M, Hes O. Sporadic hybrid oncocytic/chromophobe tumor of the kidney: a clinicopathologic, histomorphologic, immunohistochemical, ultrastructural, and molecular cytogenetic study of 14 cases. Virchows Arch. 2010 Apr; 456(4):355-65.

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Ward SC, Thung SN, Lim KH, Tran TT, Hong TK, Hoang PL, Jang JJ, Park YN, Abe K. Hepatic progenitor cells in liver cancers from Asian children. Liver Int. 2010 Jan; 30(1):102-11.

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Blume-Jensen P, Janknecht R, Hunter T. The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol. 1998 Jun 18; 8(13):779-82.

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