eIF-2 Kinase

"eIF-2 Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.

Descriptor ID	D019892
MeSH Number(s)	D08.811.913.696.620.682.700.300 D12.644.360.275 D12.776.476.275
Concept/Terms	eIF-2 Kinase eIF-2 Kinase Kinase, eIF-2 eIF 2 Kinase DAI Protein Kinase Kinase, DAI Protein Protein Kinase, DAI Double Stranded RNA-Dependent eIF-2 alpha Protein Kinase Double Stranded RNA Dependent eIF 2 alpha Protein Kinase Double Stranded RNA-Dependent Kinase (dsl) dsRNA-Activated Inhibitor Inhibitor, dsRNA-Activated dsRNA Activated Inhibitor DSRNA-Dep Protein Kinase DSRNA Dep Protein Kinase Kinase, DSRNA-Dep Protein Protein Kinase, DSRNA-Dep eIF-2alpha Kinase Kinase, eIF-2alpha eIF 2alpha Kinase eRF, eIF-2 Recycling Factor eRF, eIF 2 Recycling Factor Eukaryotic Initiation Factor 2alpha Kinase Heme Controlled Repressor Controlled Repressor, Heme Repressor, Heme Controlled Heme-Controlled Inhibitor Heme Controlled Inhibitor Inhibitor, Heme-Controlled Heme-Regulated eIF-2alpha Kinase Heme Regulated eIF 2alpha Kinase Kinase, Heme-Regulated eIF-2alpha eIF-2alpha Kinase, Heme-Regulated Hemin Controlled Repressor Controlled Repressor, Hemin Repressor, Hemin Controlled p68 Kinase Kinase, p68 Self-Phosphorylating Protein Kinase Kinase, Self-Phosphorylating Protein Protein Kinase, Self-Phosphorylating Self Phosphorylating Protein Kinase TIK Kinase Kinase, TIK P68 Protein Kinase Kinase, P68 Protein Protein Kinase, P68 RNA-Dependent Protein Kinase Kinase, RNA-Dependent Protein Protein Kinase, RNA-Dependent RNA Dependent Protein Kinase p65 Kinase Kinase, p65 Protein Kinase PKR Kinase PKR, Protein PKR, Protein Kinase Protein Kinase, RNA Activated Heme-Controlled Translational Repressor Heme Controlled Translational Repressor Repressor, Heme-Controlled Translational Translational Repressor, Heme-Controlled Hemin-Controlled Translational Repressor Hemin Controlled Translational Repressor Repressor, Hemin-Controlled Translational Translational Repressor, Hemin-Controlled

Below are MeSH descriptors whose meaning is more general than "eIF-2 Kinase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
eIF-2 Kinase [D08.811.913.696.620.682.700.300]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
eIF-2 Kinase [D12.644.360.275]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
eIF-2 Kinase [D12.776.476.275]

Below are MeSH descriptors whose meaning is related to "eIF-2 Kinase".

Below are MeSH descriptors whose meaning is more specific than "eIF-2 Kinase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "eIF-2 Kinase" by people in this website by year, and whether "eIF-2 Kinase" was a major or minor topic of these publications.

Bar chart showing 23 publications over 15 distinct years, with a maximum of 3 publications in 1997 and 2002

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	0	1	1
1997	0	3	3
1998	2	0	2
1999	1	0	1
2000	2	0	2
2001	2	0	2
2002	2	1	3
2003	1	0	1
2004	0	2	2
2005	1	0	1
2007	0	1	1
2009	0	1	1
2013	0	1	1
2015	0	1	1
2024	1	0	1

Below are the most recent publications written about "eIF-2 Kinase" by people in Profiles.

PKR activation-induced mitochondrial dysfunction in HIV-transgenic mice with nephropathy. Elife. 2024 Aug 29; 12.

View in: PubMed
Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells. Cancer Lett. 2016 Feb 28; 371(2):347-53.

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Progesterone enhances calcitriol antitumor activity by upregulating vitamin D receptor expression and promoting apoptosis in endometrial cancer cells. Cancer Prev Res (Phila). 2013 Jul; 6(7):731-43.

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Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Mol Cell Biol. 2009 Aug; 29(15):4295-307.

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Delivery of Interferon-gamma by an adenovirus vector blocks herpes simplex virus Type 1 reactivation in vitro and in vivo independent of RNase L and double-stranded RNA-dependent protein kinase pathways. J Neuroimmunol. 2009 Jan 03; 206(1-2):39-43.

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CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. Hepatology. 2007 May; 45(5):1108-17.

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Oligoadenylate synthetase/protein kinase R pathways and alphabeta TCR+ T cells are required for adenovirus vector: IFN-gamma inhibition of herpes simplex virus-1 in cornea. J Immunol. 2007 Apr 15; 178(8):5166-72.

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The lack of RNA-dependent protein kinase enhances susceptibility of mice to genital herpes simplex virus type 2 infection. Immunology. 2006 Aug; 118(4):520-6.

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OAS and PKR are not required for the antiviral effect of Ad:IFN-gamma against acute HSV-1 in primary trigeminal ganglia cultures. J Interferon Cytokine Res. 2006 Apr; 26(4):220-5.

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Interdomain interactions regulate the activation of the heme-regulated eIF 2 alpha kinase. Biochim Biophys Acta. 2005 Sep 15; 1725(2):174-81.

View in: PubMed

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