"rho-Associated Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
| Descriptor ID |
D054460
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.814 D12.644.360.590 D12.776.476.595
|
| Concept/Terms |
rho-Associated Kinases- rho-Associated Kinases
- rho Associated Kinases
- rho-Associated Kinase
- rho Associated Kinase
- ROCK Protein Kinases
- Protein Kinases, ROCK
- rho-Associated Coiled-Coil Kinase
- Coiled-Coil Kinase, rho-Associated
- rho Associated Coiled Coil Kinase
- rho-Kinase
- rho Kinase
- ROK Kinase
rho-Associated Kinase 1- rho-Associated Kinase 1
- rho Associated Kinase 1
- ROCK-I Protein Kinase
- ROCK I Protein Kinase
- p160ROCK
- rho-Associated Kinase beta
- rho Associated Kinase beta
- rho-Associated Protein Kinase beta
- rho Associated Protein Kinase beta
- rho-Associated Coiled-Coil Containing Protein Kinase 1
- rho Associated Coiled Coil Containing Protein Kinase 1
rho-Associated Kinase 2- rho-Associated Kinase 2
- rho Associated Kinase 2
- rho-Associated Kinase alpha
- rho Associated Kinase alpha
- rho-Associated Coiled-Coil Containing Protein Kinase 2
- rho Associated Coiled Coil Containing Protein Kinase 2
- ROCK-II Protein Kinase
- ROCK II Protein Kinase
- p160 rhoA-Binding Kinase ROKalpha
- p160 rhoA Binding Kinase ROKalpha
- rho-Associated Protein Kinase alpha
- rho Associated Protein Kinase alpha
|
Below are MeSH descriptors whose meaning is more general than "rho-Associated Kinases".
Below are MeSH descriptors whose meaning is more specific than "rho-Associated Kinases".
This graph shows the total number of publications written about "rho-Associated Kinases" by people in this website by year, and whether "rho-Associated Kinases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 1 | 1 | 2 |
| 2011 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "rho-Associated Kinases" by people in Profiles.
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ROCK1 inhibitor stabilizes E-cadherin and improves barrier function in experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2020 04 01; 318(4):G781-G792.
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Caveolin 1 is Associated with Upregulated Claudin 2 in Necrotizing Enterocolitis. Sci Rep. 2019 03 21; 9(1):4982.
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Rho kinase inhibition maintains intestinal and vascular barrier function by upregulation of occludin in experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2018 10 01; 315(4):G514-G528.
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The volatile anesthetic isoflurane increases endothelial adenosine generation via microparticle ecto-5'-nucleotidase (CD73) release. PLoS One. 2014; 9(6):e99950.
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Improving viability and transfection efficiency with human umbilical cord wharton's jelly cells through use of a ROCK inhibitor. Cell Reprogram. 2014 Apr; 16(2):91-7.
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ß-Escin inhibits NNK-induced lung adenocarcinoma and ALDH1A1 and RhoA/Rock expression in A/J mice and growth of H460 human lung cancer cells. Cancer Prev Res (Phila). 2013 Oct; 6(10):1140-9.
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Inhibition of sphingosine 1-phosphate receptor 2 protects against renal ischemia-reperfusion injury. J Am Soc Nephrol. 2012 Feb; 23(2):266-80.
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Altered contribution of RhoA/Rho kinase signaling in contractile activity of myometrium in leptin receptor-deficient mice. Am J Physiol Endocrinol Metab. 2011 Aug; 301(2):E362-9.
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Endothelial nitric oxide synthase inhibits G12/13 and rho-kinase activated by the angiotensin II type-1 receptor: implication in vascular migration. Arterioscler Thromb Vasc Biol. 2009 Feb; 29(2):217-24.
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Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats. Cardiovasc Res. 2008 Jul 15; 79(2):322-30.