WNK Lysine-Deficient Protein Kinase 1
"WNK Lysine-Deficient Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.
| Descriptor ID |
D000076204
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| MeSH Number(s) |
D08.811.913.696.620.682.700.982 D12.644.360.975 D12.776.476.944 D23.050.301.500.600.962 D23.050.705.552.600.925
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "WNK Lysine-Deficient Protein Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "WNK Lysine-Deficient Protein Kinase 1".
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Below are the most recent publications written about "WNK Lysine-Deficient Protein Kinase 1" by people in Profiles.
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WNK1 Enhances Migration and Invasion in Breast Cancer Models. Mol Cancer Ther. 2021 10; 20(10):1800-1808.