"I-kappa B Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.
| Descriptor ID |
D051550
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| MeSH Number(s) |
D08.811.913.696.620.682.700.494 D12.644.360.361 D12.776.476.378
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| Concept/Terms |
I-kappa B Kinase- I-kappa B Kinase
- B Kinase, I-kappa
- Kinase, I-kappa B
- NK-kappa B-Activating Kinase NAK
- NK kappa B Activating Kinase NAK
- IkappaB Kinase
- Kinase, IkappaB
- I kappa B Kinase
IkappaB Kinase gamma- IkappaB Kinase gamma
- IKK gamma
- NF-kappaB Essential Modifier
- Essential Modifier, NF-kappaB
- NF kappaB Essential Modifier
IkappaB Kinase alpha- IkappaB Kinase alpha
- Kinase alpha, IkappaB
- IKK 1 Kinase
- IKK alpha
- Conserved Helix-Loop-Helix Ubiquitous Kinase
- Conserved Helix Loop Helix Ubiquitous Kinase
- CHUK Kinase
- I Kappa B alpha-Associated Protein Kinase
- I Kappa B alpha Associated Protein Kinase
- IkappaBalpha Kinase
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Below are MeSH descriptors whose meaning is more general than "I-kappa B Kinase".
Below are MeSH descriptors whose meaning is more specific than "I-kappa B Kinase".
This graph shows the total number of publications written about "I-kappa B Kinase" by people in this website by year, and whether "I-kappa B Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "I-kappa B Kinase" by people in Profiles.
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Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis. World J Gastroenterol. 2017 Oct 07; 23(37):6802-6816.
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Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling. Stem Cell Res Ther. 2015 Feb 20; 6:2.
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Estrogen suppresses heptatic I?B expression during short-term alcohol exposure. Inflamm Res. 2012 Oct; 61(10):1053-61.
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Irreversible EGFR inhibitor EKB-569 targets low-LET ?-radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma. PLoS One. 2011; 6(12):e29705.
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Status of bacterial colonization, Toll-like receptor expression and nuclear factor-kappa B activation in normal and diseased human livers. Clin Immunol. 2011 Jan; 138(1):41-9.
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NF-kappaB is involved in SHetA2 circumvention of TNF-alpha resistance, but not induction of intrinsic apoptosis. Anticancer Drugs. 2010 Mar; 21(3):297-305.
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Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 2007 Jun 15; 129(6):1065-79.
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An alternative splice product of IkappaB kinase (IKKgamma), IKKgamma-delta, differentially mediates cytokine and human T-cell leukemia virus type 1 tax-induced NF-kappaB activation. J Virol. 2006 May; 80(9):4227-41.
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IkappaB kinase is a critical regulator of chemokine expression and lung inflammation in respiratory syncytial virus infection. J Virol. 2004 Mar; 78(5):2232-41.