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Leonidas Tsiokas

TitleProf,George L Cross Rsrch &Chr
InstitutionUniversity of Oklahoma Health Sciences Center
DepartmentCell Biology
AddressBRC 262
975 NE 10th St
Oklahoma City OK 73104
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    Collapse Research 
    Collapse research activities and funding
    R01DK138339     (TSIOKAS, LEONIDAS)Aug 15, 2024 - May 31, 2028
    NIH
    Role of FBW7 in cystic diseases of the kidney
    Role: Principal Investigator
    R25GM144169     (HOWARD, ERIC W)Mar 17, 2023 - Feb 28, 2028
    NIH
    Post-Baccalaureate Research and Education Program (PREP) for Oklahoma
    Role: Co-Principal Investigator
    R01DK126705     (TSIOKAS, LEONIDAS)Mar 15, 2021 - Jan 31, 2025
    NIH
    Ciliary Disassembly, a modifier of Autosomal Dominant Polycystic Kidney Disease
    Role: Principal Investigator
    R01DK121656     (CHANG, WENHAN ;TSIOKAS, LEONIDAS)Apr 1, 2019 - Mar 31, 2024
    NIH
    Regulation of PTH secretion by TRPC1
    Role: Principal Investigator
    R56DK117654     (TSIOKAS, LEONIDAS)Sep 20, 2018 - Aug 31, 2020
    NIH
    Ciliary disassembly, a modifier of Polycystic Kidney Disease
    Role: Principal Investigator
    R01AR064211     (TSIOKAS, LEONIDAS)Sep 17, 2013 - Aug 31, 2019
    NIH
    Calcium Regulation in Osteoclasts
    Role: Principal Investigator
    R56DK059599     (TSIOKAS, LEONIDAS)Sep 1, 2010 - Aug 31, 2011
    NIH
    Regulation of calcium signaling by the PKD2 gene product
    Role: Principal Investigator
    R01DK059599     (TSIOKAS, LEONIDAS)Apr 1, 2001 - Apr 30, 2021
    NIH
    Regulation of calcium signaling by the PKD2 gene product
    Role: Principal Investigator
    F32DK009625     (TSIOKAS, LEONIDAS)Oct 5, 1997
    NIH
    STRUCTURE/FUNCTION ANALYSIS OF K CADHERIN
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Atkins RM, Pantalia M, Skaggs C, Lau AK, Mahmood MB, Anwar MM, Barron L, Eby B, Khan U, Tsiokas L, Lau K. Normotensive metabolic syndrome in Transient Receptor Potential Canonical Channel type 1 Trpc1-/- mice. Biol Open. 2024 Jul 15; 13(7). PMID: 38885005; PMCID: PMC11317093.
      Citations:    Fields:    Translation:Animals
    2. Elechalawar CK, Rao G, Gulla SK, Patel MM, Frickenstein A, Means N, Roy RV, Tsiokas L, Asfa S, Panja P, Rao C, Wilhelm S, Bhattacharya R, Mukherjee P. Correction to "Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation". ACS Nano. 2024 Mar 26; 18(12):9242. PMID: 38465974.
      Citations:    Fields:    
    3. Patel MM, Gerakopoulos V, Petsouki E, Zimmerman KA, Tsiokas L. Nephronophthisis-associated FBW7 mediates cyst-dependent decline of renal function in ADPKD. bioRxiv. 2024 Mar 02. PMID: 38464230; PMCID: PMC10925305.
      Citations:    
    4. Houser JS, Patel M, Wright K, Onopiuk M, Tsiokas L, Humphrey MB. The inhibitor of MyoD Family A (I-MFA) regulates megakaryocyte lineage commitment and terminal differentiation. Blood Cells Mol Dis. 2023 09; 102:102760. PMID: 37267696.
      Citations:    Fields:    Translation:AnimalsCells
    5. Elechalawar CK, Rao G, Gulla SK, Patel MM, Frickenstein A, Means N, Roy RV, Tsiokas L, Asfa S, Panja P, Rao C, Wilhelm S, Bhattacharya R, Mukherjee P. Gold Nanoparticles Inhibit Macropinocytosis by Decreasing KRAS Activation. ACS Nano. 2023 May 02. PMID: 37129853.
      Citations:    Fields:    Translation:HumansCells
    6. Song CJ, Li Z, Ahmed UKB, Bland SJ, Yashchenko A, Liu S, Aloria EJ, Lever JM, Gonzalez NM, Bickel MA, Giles CB, Georgescu C, Wren JD, Lang ML, Benveniste EN, Harrington LE, Tsiokas L, George JF, Jones KL, Crossman DK, Agarwal A, Mrug M, Yoder BK, Hopp K, Zimmerman KA. A Comprehensive Immune Cell Atlas of Cystic Kidney Disease Reveals the Involvement of Adaptive Immune Cells in Injury-Mediated Cyst Progression in Mice. J Am Soc Nephrol. 2022 04; 33(4):747-768. PMID: 35110364.
      Citations: 5     Fields:    Translation:AnimalsCells
    7. Patel MM, Tsiokas L. Insights into the Regulation of Ciliary Disassembly. Cells. 2021 11 01; 10(11). PMID: 34831200.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    8. Petsouki E, Gerakopoulos V, Szeto N, Chang W, Humphrey MB, Tsiokas L. FBW7 couples structural integrity with functional output of primary cilia. Commun Biol. 2021 09 13; 4(1):1066. PMID: 34518642.
      Citations: 4     Translation:AnimalsCells
    9. Gerakopoulos V, Ngo P, Tsiokas L. Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway. Life Sci Alliance. 2020 09; 3(9). PMID: 32651191.
      Citations: 10     Fields:    Translation:AnimalsCells
    10. Onopiuk M, Eby B, Nesin V, Ngo P, Lerner M, Gorvin CM, Stokes VJ, Thakker RV, Brandi ML, Chang W, Humphrey MB, Tsiokas L, Lau K. Control of PTH secretion by the TRPC1 ion channel. JCI Insight. 2020 04 23; 5(8). PMID: 32213715.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Hardy E, Tsiokas L. Polycystins as components of large multiprotein complexes of polycystin interactors. Cell Signal. 2020 08; 72:109640. PMID: 32305669.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    12. Shotorbani PY, Chaudhari S, Tao Y, Tsiokas L, Ma R. Inhibitor of myogenic differentiation family isoform a, a new positive regulator of fibronectin production by glomerular mesangial cells. Am J Physiol Renal Physiol. 2020 03 01; 318(3):F673-F682. PMID: 31984795.
      Citations: 6     Fields:    Translation:AnimalsCells
    13. Gamage TH, Lengle E, Gunnes G, Pullisaar H, Holmgren A, Reseland JE, Merckoll E, Corti S, Mizobuchi M, Morales RJ, Tsiokas L, Tjønnfjord GE, Lacruz RS, Lyngstadaas SP, Misceo D, Frengen E. STIM1 R304W in mice causes subgingival hair growth and an increased fraction of trabecular bone. Cell Calcium. 2020 01; 85:102110. PMID: 31785581.
      Citations: 6     Fields:    Translation:AnimalsCells
    14. Zheng W, Cai R, Hofmann L, Nesin V, Hu Q, Long W, Fatehi M, Liu X, Hussein S, Kong T, Li J, Light PE, Tang J, Flockerzi V, Tsiokas L, Chen XZ. Direct Binding between Pre-S1 and TRP-like Domains in TRPP Channels Mediates Gating and Functional Regulation by PIP2. Cell Rep. 2018 02 06; 22(6):1560-1573. PMID: 29425510.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    15. Feng S, Streets AJ, Nesin V, Tran U, Nie H, Onopiuk M, Wessely O, Tsiokas L, Ong ACM. The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex. J Am Soc Nephrol. 2017 Oct; 28(10):2973-2984. PMID: 28620080.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    16. Chakraborty PK, Mustafi SB, Xiong X, Dwivedi SKD, Nesin V, Saha S, Zhang M, Dhanasekaran D, Jayaraman M, Mannel R, Moore K, McMeekin S, Yang D, Zuna R, Ding K, Tsiokas L, Bhattacharya R, Mukherjee P. MICU1 drives glycolysis and chemoresistance in ovarian cancer. Nat Commun. 2017 05 22; 8:14634. PMID: 28530221.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    17. Kim S, Nie H, Nesin V, Tran U, Outeda P, Bai CX, Keeling J, Maskey D, Watnick T, Wessely O, Tsiokas L. The polycystin complex mediates Wnt/Ca(2+) signalling. Nat Cell Biol. 2016 07; 18(7):752-764. PMID: 27214281.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    18. Keeling J, Tsiokas L, Maskey D. Cellular Mechanisms of Ciliary Length Control. Cells. 2016 Jan 29; 5(1). PMID: 26840332.
      Citations: 41     Fields:    
    19. Maskey D, Marlin MC, Kim S, Kim S, Ong EC, Li G, Tsiokas L. Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length. EMBO J. 2015 Oct 01; 34(19):2424-40. PMID: 26206584.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    20. Nesin V, Wiley G, Kousi M, Ong EC, Lehmann T, Nicholl DJ, Suri M, Shahrizaila N, Katsanis N, Gaffney PM, Wierenga KJ, Tsiokas L. Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4197-202. PMID: 24591628.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    21. Nesin V, Tsiokas L. TRPC1. Handb Exp Pharmacol. 2014; 222:15-51. PMID: 24756701.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    22. Ong EC, Nesin V, Long CL, Bai CX, Guz JL, Ivanov IP, Abramowitz J, Birnbaumer L, Humphrey MB, Tsiokas L. A TRPC1 protein-dependent pathway regulates osteoclast formation and function. J Biol Chem. 2013 Aug 02; 288(31):22219-32. PMID: 23770672.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    23. Foy RL, Chitalia VC, Panchenko MV, Zeng L, Lopez D, Lee JW, Rana SV, Boletta A, Qian F, Tsiokas L, Piontek KB, Germino GG, Zhou MI, Cohen HT. Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1. Hum Mol Genet. 2012 Dec 15; 21(26):5456-71. PMID: 23001567.
      Citations: 13     Fields:    Translation:HumansCells
    24. Kim S, Tsiokas L. Cilia and cell cycle re-entry: more than a coincidence. Cell Cycle. 2011 Aug 15; 10(16):2683-90. PMID: 21814045.
      Citations: 76     Fields:    Translation:HumansCells
    25. Kim S, Zaghloul NA, Bubenshchikova E, Oh EC, Rankin S, Katsanis N, Obara T, Tsiokas L. Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat Cell Biol. 2011 Apr; 13(4):351-60. PMID: 21394081.
      Citations: 141     Fields:    Translation:AnimalsCells
    26. Seth M, Zhang ZS, Mao L, Graham V, Burch J, Stiber J, Tsiokas L, Winn M, Abramowitz J, Rockman HA, Birnbaumer L, Rosenberg P. TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Res. 2009 Nov 06; 105(10):1023-30. PMID: 19797170.
      Citations: 102     Fields:    Translation:AnimalsCells
    27. Tsiokas L. Function and regulation of TRPP2 at the plasma membrane. Am J Physiol Renal Physiol. 2009 Jul; 297(1):F1-9. PMID: 19244406.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    28. Felekkis KN, Koupepidou P, Kastanos E, Witzgall R, Bai CX, Li L, Tsiokas L, Gretz N, Deltas C. Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2. BMC Nephrol. 2008 Aug 25; 9:10. PMID: 18721488.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    29. Feng S, Okenka GM, Bai CX, Streets AJ, Newby LJ, DeChant BT, Tsiokas L, Obara T, Ong AC. Identification and functional characterization of an N-terminal oligomerization domain for polycystin-2. J Biol Chem. 2008 Oct 17; 283(42):28471-9. PMID: 18701462.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    30. Bai CX, Kim S, Li WP, Streets AJ, Ong AC, Tsiokas L. Activation of TRPP2 through mDia1-dependent voltage gating. EMBO J. 2008 May 07; 27(9):1345-56. PMID: 18388856.
      Citations: 24     Fields:    Translation:AnimalsCells
    31. Bai CX, Giamarchi A, Rodat-Despoix L, Padilla F, Downs T, Tsiokas L, Delmas P. Formation of a new receptor-operated channel by heteromeric assembly of TRPP2 and TRPC1 subunits. EMBO Rep. 2008 May; 9(5):472-9. PMID: 18323855.
      Citations: 89     Fields:    Translation:AnimalsCells
    32. Kaznacheyeva E, Glushankova L, Bugaj V, Zimina O, Skopin A, Alexeenko V, Tsiokas L, Bezprozvanny I, Mozhayeva GN. Suppression of TRPC3 leads to disappearance of store-operated channels and formation of a new type of store-independent channels in A431 cells. J Biol Chem. 2007 Aug 10; 282(32):23655-62. PMID: 17569672.
      Citations: 11     Fields:    Translation:HumansCells
    33. Tsiokas L, Kim S, Ong EC. Cell biology of polycystin-2. Cell Signal. 2007 Mar; 19(3):444-53. PMID: 17084592.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    34. Pan W, Jia Y, Wang J, Tao D, Gan X, Tsiokas L, Jing N, Wu D, Li L. Beta-catenin regulates myogenesis by relieving I-mfa-mediated suppression of myogenic regulatory factors in P19 cells. Proc Natl Acad Sci U S A. 2005 Nov 29; 102(48):17378-83. PMID: 16301527.
      Citations: 24     Fields:    Translation:AnimalsCells
    35. Ma R, Li WP, Rundle D, Kong J, Akbarali HI, Tsiokas L. PKD2 functions as an epidermal growth factor-activated plasma membrane channel. Mol Cell Biol. 2005 Sep; 25(18):8285-98. PMID: 16135816.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    36. Rajala RV, McClellan ME, Chan MD, Tsiokas L, Anderson RE. Interaction of the retinal insulin receptor beta-subunit with the p85 subunit of phosphoinositide 3-kinase. Biochemistry. 2004 May 18; 43(19):5637-50. PMID: 15134438.
      Citations: 25     Fields:    Translation:AnimalsCells
    37. Rundle DR, Gorbsky G, Tsiokas L. PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles. J Biol Chem. 2004 Jul 09; 279(28):29728-39. PMID: 15123714.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    38. Li WP, Tsiokas L, Sansom SC, Ma R. Epidermal growth factor activates store-operated Ca2+ channels through an inositol 1,4,5-trisphosphate-independent pathway in human glomerular mesangial cells. J Biol Chem. 2004 Feb 06; 279(6):4570-7. PMID: 14612458.
      Citations: 17     Fields:    Translation:HumansCells
    39. Ma R, Rundle D, Jacks J, Koch M, Downs T, Tsiokas L. Inhibitor of myogenic family, a novel suppressor of store-operated currents through an interaction with TRPC1. J Biol Chem. 2003 Dec 26; 278(52):52763-72. PMID: 14530267.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    40. Ong HL, Chen J, Chataway T, Brereton H, Zhang L, Downs T, Tsiokas L, Barritt G. Specific detection of the endogenous transient receptor potential (TRP)-1 protein in liver and airway smooth muscle cells using immunoprecipitation and Western-blot analysis. Biochem J. 2002 Jun 15; 364(Pt 3):641-8. PMID: 12049627.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    41. Karumanchi SA, Jha V, Ramchandran R, Karihaloo A, Tsiokas L, Chan B, Dhanabal M, Hanai JI, Venkataraman G, Shriver Z, Keiser N, Kalluri R, Zeng H, Mukhopadhyay D, Chen RL, Lander AD, Hagihara K, Yamaguchi Y, Sasisekharan R, Cantley L, Sukhatme VP. Cell surface glypicans are low-affinity endostatin receptors. Mol Cell. 2001 Apr; 7(4):811-22. PMID: 11336704.
      Citations: 72     Fields:    Translation:AnimalsCells
    42. Hanaoka K, Qian F, Boletta A, Bhunia AK, Piontek K, Tsiokas L, Sukhatme VP, Guggino WB, Germino GG. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature. 2000 Dec 21-28; 408(6815):990-4. PMID: 11140688.
      Citations: 313     Fields:    Translation:HumansAnimalsCells
    43. Kim E, Arnould T, Sellin L, Benzing T, Comella N, Kocher O, Tsiokas L, Sukhatme VP, Walz G. Interaction between RGS7 and polycystin. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6371-6. PMID: 10339594.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    44. Arnould T, Sellin L, Benzing T, Tsiokas L, Cohen HT, Kim E, Walz G. Cellular activation triggered by the autosomal dominant polycystic kidney disease gene product PKD2. Mol Cell Biol. 1999 May; 19(5):3423-34. PMID: 10207066.
      Citations: 21     Fields:    Translation:HumansCells
    45. Tsiokas L, Arnould T, Zhu C, Kim E, Walz G, Sukhatme VP. Specific association of the gene product of PKD2 with the TRPC1 channel. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3934-9. PMID: 10097141.
      Citations: 110     Fields:    Translation:HumansCells
    46. Arnould T, Kim E, Tsiokas L, Jochimsen F, Grüning W, Chang JD, Walz G. The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1. J Biol Chem. 1998 Mar 13; 273(11):6013-8. PMID: 9497315.
      Citations: 58     Fields:    Translation:HumansCells
    47. Mukhopadhyay D, Tsiokas L, Sukhatme VP. High cell density induces vascular endothelial growth factor expression via protein tyrosine phosphorylation. Gene Expr. 1998; 7(1):53-60. PMID: 9572397.
      Citations: 2     Fields:    Translation:HumansCells
    48. Tsiokas L, Kim E, Arnould T, Sukhatme VP, Walz G. Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6965-70. PMID: 9192675.
      Citations: 174     Fields:    Translation:HumansCells
    49. Mukhopadhyay D, Tsiokas L, Sukhatme VP. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res. 1995 Dec 15; 55(24):6161-5. PMID: 8521408.
      Citations: 92     Fields:    Translation:HumansCells
    50. Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature. 1995 Jun 15; 375(6532):577-81. PMID: 7540725.
      Citations: 138     Fields:    Translation:AnimalsCells
    51. Tsiokas L, Watson M. Differential in vivo induction of immediate early genes by oxotremorine in the central nervous system of long- and short-sleep mice. Mol Pharmacol. 1995 Feb; 47(2):272-82. PMID: 7870035.
      Citations:    Fields:    Translation:AnimalsCells
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