"c-Mer Tyrosine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.
| Descriptor ID |
D000076202
|
| MeSH Number(s) |
D08.811.913.696.620.682.725.400.003 D12.776.543.750.630.003 D12.776.624.664.700.037
|
| Concept/Terms |
c-Mer Tyrosine Kinase- c-Mer Tyrosine Kinase
- Kinase, c-Mer Tyrosine
- Tyrosine Kinase, c-Mer
- c Mer Tyrosine Kinase
- c-Mer Proto-Oncogene Tyrosine Kinase
- c Mer Proto Oncogene Tyrosine Kinase
- MERTK
|
Below are MeSH descriptors whose meaning is more general than "c-Mer Tyrosine Kinase".
Below are MeSH descriptors whose meaning is more specific than "c-Mer Tyrosine Kinase".
This graph shows the total number of publications written about "c-Mer Tyrosine Kinase" by people in this website by year, and whether "c-Mer Tyrosine Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2010 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "c-Mer Tyrosine Kinase" by people in Profiles.
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Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3. Immunohorizons. 2024 Mar 01; 8(3):269-280.
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Defective Efferocytosis in a Murine Model of Sjögren's Syndrome Is Mediated by Dysfunctional Mer Tyrosine Kinase Receptor. Int J Mol Sci. 2021 Sep 08; 22(18).
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Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling. Int J Mol Sci. 2019 Mar 07; 20(5).
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UNC569, a novel small-molecule mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Mol Cancer Ther. 2013 Nov; 12(11):2367-77.
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TAM receptor ligands in lupus: protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus. Arthritis Res Ther. 2010; 12(4):R146.