"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
- Protein Phosphatase 3
- Phosphatase 3, Protein
- Protein Phosphatase-2B
- Protein Phosphatase 2B
- Calcineurin B
- Protein Phosphatase 3 Regulatory Subunit
- Calcineurin A
- Protein Phosphatase 3 Catalytic Subunit
Below are MeSH descriptors whose meaning is more general than "Calcineurin".
Below are MeSH descriptors whose meaning is more specific than "Calcineurin".
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Below are the most recent publications written about "Calcineurin" by people in Profiles.
Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors. Mol Endocrinol. 2014 May; 28(5):659-73.
Regulation of GATA-3 expression during CD4 lineage differentiation. J Immunol. 2011 Apr 01; 186(7):3892-8.
TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Res. 2009 Nov 06; 105(10):1023-30.
Calcineurin nephrotoxicity. Adv Chronic Kidney Dis. 2006 Jan; 13(1):47-55.
Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. J Biol Chem. 2004 Oct 22; 279(43):44606-12.
Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members. Biochem Biophys Res Commun. 2001 Oct 19; 288(1):233-9.
Regulation of tumor necrosis factor cytotoxicity by calcineurin. FEBS Lett. 2000 Oct 20; 483(2-3):119-24.