"Calcineurin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A CALCIUM and CALMODULIN-dependent serine/threonine protein phosphatase that is composed of the calcineurin A catalytic subunit and the calcineurin B regulatory subunit. Calcineurin has been shown to dephosphorylate a number of phosphoproteins including HISTONES; MYOSIN LIGHT CHAIN; and the regulatory subunits of CAMP-DEPENDENT PROTEIN KINASES. It is involved in the regulation of signal transduction and is the target of an important class of immunophilin-immunosuppressive drug complexes.
| Descriptor ID |
D019703
|
| MeSH Number(s) |
D08.811.277.352.650.625.150 D12.644.360.087 D12.776.476.087
|
| Concept/Terms |
Calcineurin- Calcineurin
- Protein Phosphatase 3
- Phosphatase 3, Protein
- Protein Phosphatase-2B
- Protein Phosphatase 2B
Calcineurin B- Calcineurin B
- Protein Phosphatase 3 Regulatory Subunit
Calcineurin A- Calcineurin A
- Protein Phosphatase 3 Catalytic Subunit
|
Below are MeSH descriptors whose meaning is more general than "Calcineurin".
Below are MeSH descriptors whose meaning is more specific than "Calcineurin".
This graph shows the total number of publications written about "Calcineurin" by people in this website by year, and whether "Calcineurin" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
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Below are the most recent publications written about "Calcineurin" by people in Profiles.
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Synthetic FXR agonist GW4064 is a modulator of multiple G protein-coupled receptors. Mol Endocrinol. 2014 May; 28(5):659-73.
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Regulation of GATA-3 expression during CD4 lineage differentiation. J Immunol. 2011 Apr 01; 186(7):3892-8.
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TRPC1 channels are critical for hypertrophic signaling in the heart. Circ Res. 2009 Nov 06; 105(10):1023-30.
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Calcineurin nephrotoxicity. Adv Chronic Kidney Dis. 2006 Jan; 13(1):47-55.
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Platelet-activating factor-induced chemokine gene expression requires NF-kappaB activation and Ca2+/calcineurin signaling pathways. Inhibition by receptor phosphorylation and beta-arrestin recruitment. J Biol Chem. 2004 Oct 22; 279(43):44606-12.
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Phosphorylation of human N-myristoyltransferase by N-myristoylated SRC family tyrosine kinase members. Biochem Biophys Res Commun. 2001 Oct 19; 288(1):233-9.
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Regulation of tumor necrosis factor cytotoxicity by calcineurin. FEBS Lett. 2000 Oct 20; 483(2-3):119-24.