Proto-Oncogene Proteins c-bcr
"Proto-Oncogene Proteins c-bcr" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A serine-threonine kinase that contains a C2 DOMAIN and PLECKSTRIN HOMOLOGY DOMAIN. It also has activity as a GTPASE-ACTIVATING PROTEIN for RAC1 PROTEIN and CDC42 PROTEIN. It functions as a negative regulator of CELL PROLIFERATION and NEOPLASTIC CELL TRANSFORMATION and is commonly fused with cellular abl protein to form BCR-ABL FUSION PROTEINS in PHILADELPHIA CHROMOSOME positive LEUKEMIA patients.
Descriptor ID |
D051562
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MeSH Number(s) |
D08.811.913.696.620.682.700.759 D12.644.360.325.300.099.500 D12.776.476.325.300.099.500 D12.776.624.664.700.171
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Concept/Terms |
Proto-Oncogene Proteins c-bcr- Proto-Oncogene Proteins c-bcr
- Proto Oncogene Proteins c bcr
- c-bcr, Proto-Oncogene Proteins
- Proto-Oncogene Protein c-bcr
- Proto Oncogene Protein c bcr
- c-bcr, Proto-Oncogene Protein
- Breakpoint Cluster Region Protein
- c-bcr Proteins
- c bcr Proteins
- c-bcr Proto-Oncogene Proteins
- Proto-Oncogene Proteins, c-bcr
- c bcr Proto Oncogene Proteins
- bcr Proto-Oncogene Proteins
- Proto-Oncogene Proteins, bcr
- bcr Proto Oncogene Proteins
- Proto-Oncogene Protein bcr
- Proto Oncogene Protein bcr
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Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-bcr".
Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-bcr".
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Below are the most recent publications written about "Proto-Oncogene Proteins c-bcr" by people in Profiles.
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Pharmacoethnicity in Paclitaxel-Induced Sensory Peripheral Neuropathy. Clin Cancer Res. 2015 Oct 01; 21(19):4337-46.
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Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation. Genomics. 1995 May 01; 27(1):67-82.