Tumor Necrosis Factor alpha-Induced Protein 3
"Tumor Necrosis Factor alpha-Induced Protein 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A UBIQUITIN editing enzyme that functions as both a ubiquitin ligase and deubiquitinase. It contains several ZINC FINGERS and functions in the immune response and INFLAMMATION by modulating signals from TNF-ALPHA; IL1-BETA; or pathogens via TOLL-LIKE RECEPTORS to terminate NF-KAPPA B activity.
| Descriptor ID |
D000072598
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| MeSH Number(s) |
D08.811.037.750.500 D08.811.277.656.300.887.750 D08.811.464.938.750.813 D12.644.360.950 D12.776.476.938
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tumor Necrosis Factor alpha-Induced Protein 3".
Below are MeSH descriptors whose meaning is more specific than "Tumor Necrosis Factor alpha-Induced Protein 3".
This graph shows the total number of publications written about "Tumor Necrosis Factor alpha-Induced Protein 3" by people in this website by year, and whether "Tumor Necrosis Factor alpha-Induced Protein 3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 2 | 3 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tumor Necrosis Factor alpha-Induced Protein 3" by people in Profiles.
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An incoherent feedforward loop interprets NF?B/RelA dynamics to determine TNF-induced necroptosis decisions. Mol Syst Biol. 2020 12; 16(12):e9677.
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Genetics in Sjögren Syndrome. Rheum Dis Clin North Am. 2016 08; 42(3):435-47.
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Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans. Arthritis Rheumatol. 2016 05; 68(5):1197-1209.
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TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus. Genes Immun. 2016 04; 17(3):165-70.
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Germline variation of TNFAIP3 in primary Sjögren's syndrome-associated lymphoma. Ann Rheum Dis. 2016 Apr; 75(4):780-3.
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Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren's syndrome. Blood. 2013 Dec 12; 122(25):4068-76.
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An enhancer element harboring variants associated with systemic lupus erythematosus engages the TNFAIP3 promoter to influence A20 expression. PLoS Genet. 2013; 9(9):e1003750.
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Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus. Arthritis Rheum. 2012 Jan; 64(1):222-31.
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Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet. 2011 Mar; 43(3):253-8.
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Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations. Genes Immun. 2009 Jul; 10(5):470-7.