Histocompatibility Antigens Class II

"Histocompatibility Antigens Class II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.

Descriptor ID	D000949
MeSH Number(s)	D12.776.395.550.509 D12.776.543.550.440 D23.050.301.500.400 D23.050.705.552.410
Concept/Terms	Histocompatibility Antigens Class II Histocompatibility Antigens Class II Class II Antigens Antigens, Class II Class II Histocompatibility Antigens Ia-Like Antigens Antigens, Ia-Like Ia Like Antigens IA Antigen Antigen, IA I-A Antigen Antigen, I-A Antigens, Immune Response Immune Response Antigens Immune-Response-Associated Antigens Antigens, Immune-Response-Associated Immune Response Associated Antigens Class II Major Histocompatibility Antigens I-A-Antigen I A Antigen Class II Antigen Antigen, Class II Ia Antigens Antigens, Ia Immune-Associated Antigens Immune-Associated Antigens Antigens, Immune-Associated Immune Associated Antigens

Below are MeSH descriptors whose meaning is more general than "Histocompatibility Antigens Class II".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Glycoproteins [D12.776.395]
Membrane Glycoproteins [D12.776.395.550]
Histocompatibility Antigens Class II [D12.776.395.550.509]
Membrane Proteins [D12.776.543]
Membrane Glycoproteins [D12.776.543.550]
Histocompatibility Antigens Class II [D12.776.543.550.440]
Biological Factors [D23]
Antigens [D23.050]
Antigens, Surface [D23.050.301]
Histocompatibility Antigens [D23.050.301.500]
Histocompatibility Antigens Class II [D23.050.301.500.400]
Isoantigens [D23.050.705]
Histocompatibility Antigens [D23.050.705.552]
Histocompatibility Antigens Class II [D23.050.705.552.410]

Below are MeSH descriptors whose meaning is related to "Histocompatibility Antigens Class II".

Below are MeSH descriptors whose meaning is more specific than "Histocompatibility Antigens Class II".

Histocompatibility Antigens Class II
HLA-D Antigens

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Histocompatibility Antigens Class II" by people in this website by year, and whether "Histocompatibility Antigens Class II" was a major or minor topic of these publications.

Bar chart showing 37 publications over 19 distinct years, with a maximum of 5 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
1996	1	0	1
1998	1	0	1
1999	0	1	1
2000	0	1	1
2001	1	1	2
2003	1	1	2
2004	1	2	3
2006	1	2	3
2007	3	2	5
2008	1	2	3
2009	0	1	1
2010	1	1	2
2011	1	0	1
2013	0	4	4
2014	1	1	2
2018	1	0	1
2019	2	0	2
2020	0	1	1

Below are the most recent publications written about "Histocompatibility Antigens Class II" by people in Profiles.

Kaabinejadian S, Barra C, Alvarez B, Yari H, Hildebrand WH, Nielsen M. Accurate MHC Motif Deconvolution of Immunopeptidomics Data Reveals a Significant Contribution of DRB3, 4 and 5 to the Total DR Immunopeptidome. Front Immunol. 2022; 13:835454.

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Reynisson B, Barra C, Kaabinejadian S, Hildebrand WH, Peters B, Nielsen M. Improved Prediction of MHC II Antigen Presentation through Integration and Motif Deconvolution of Mass Spectrometry MHC Eluted Ligand Data. J Proteome Res. 2020 06 05; 19(6):2304-2315.

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Molineros JE, Looger LL, Kim K, Okada Y, Terao C, Sun C, Zhou XJ, Raj P, Kochi Y, Suzuki A, Akizuki S, Nakabo S, Bang SY, Lee HS, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Zuo X, Yamamoto K, Li QZ, Shen N, Porter LL, Harley JB, Chua KH, Zhang H, Wakeland EK, Tsao BP, Bae SC, Nath SK. Amino acid signatures of HLA Class-I and II molecules are strongly associated with SLE susceptibility and autoantibody production in Eastern Asians. PLoS Genet. 2019 04; 15(4):e1008092.

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Zimmerman KA, Bentley MR, Lever JM, Li Z, Crossman DK, Song CJ, Liu S, Crowley MR, George JF, Mrug M, Yoder BK. Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species. J Am Soc Nephrol. 2019 05; 30(5):767-781.

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Royer DJ, Elliott MH, Le YZ, Carr DJJ. Corneal Epithelial Cells Exhibit Myeloid Characteristics and Present Antigen via MHC Class II. Invest Ophthalmol Vis Sci. 2018 03 01; 59(3):1512-1522.

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Kroll CM, Zheng M, Carr DJ. Enhanced resistance of CXCR3 deficient mice to ocular HSV-1 infection is due to control of replication in the brain ependyma. J Neuroimmunol. 2014 Nov 15; 276(1-2):219-23.

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Graham DB, Osborne DG, Piotrowski JT, Gomez TS, Gmyrek GB, Akilesh HM, Dani A, Billadeau DD, Swat W. Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming. PLoS One. 2014; 9(6):e98606.

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Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Jazebi H, Cunninghame Graham DS, Grandits ME, Nazmul-Hossain AN, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJ, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF, Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet. 2013 Nov; 45(11):1284-92.

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Davidson MG, Alonso MN, Yuan R, Axtell RC, Kenkel JA, Suhoski MM, González JC, Steinman L, Engleman EG. Th17 cells induce Th1-polarizing monocyte-derived dendritic cells. J Immunol. 2013 Aug 01; 191(3):1175-87.

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Atanu FO, Oviedo-Orta E, Watson KA. A novel transport mechanism for MOMP in Chlamydophila pneumoniae and its putative role in immune-therapy. PLoS One. 2013; 8(4):e61139.

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