Tumor Suppressor Protein p53

"Tumor Suppressor Protein p53" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.

Descriptor ID	D016159
MeSH Number(s)	D12.776.157.687.650 D12.776.260.820 D12.776.624.776.775 D12.776.660.720.650 D12.776.744.845
Concept/Terms	Tumor Suppressor Protein p53 Tumor Suppressor Protein p53 p53 Antigen TP53 Protein TRP53 Protein p53 Tumor Suppressor Protein pp53 Phosphoprotein Phosphoprotein, pp53 Cellular Tumor Antigen p53 Oncoprotein p53

Below are MeSH descriptors whose meaning is more general than "Tumor Suppressor Protein p53".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Poly-ADP-Ribose Binding Proteins [D12.776.157.687]
Tumor Suppressor Protein p53 [D12.776.157.687.650]
DNA-Binding Proteins [D12.776.260]
Tumor Suppressor Protein p53 [D12.776.260.820]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Tumor Suppressor Protein p53 [D12.776.624.776.775]
Nuclear Proteins [D12.776.660]
Poly-ADP-Ribose Binding Proteins [D12.776.660.720]
Tumor Suppressor Protein p53 [D12.776.660.720.650]
Phosphoproteins [D12.776.744]
Tumor Suppressor Protein p53 [D12.776.744.845]

Below are MeSH descriptors whose meaning is related to "Tumor Suppressor Protein p53".

Below are MeSH descriptors whose meaning is more specific than "Tumor Suppressor Protein p53".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Tumor Suppressor Protein p53" by people in this website by year, and whether "Tumor Suppressor Protein p53" was a major or minor topic of these publications.

Bar chart showing 71 publications over 26 distinct years, with a maximum of 6 publications in 2006 and 2013 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	1	2
1995	1	0	1
1996	0	2	2
1997	0	3	3
1998	0	2	2
1999	1	1	2
2001	1	2	3
2002	0	2	2
2003	1	1	2
2004	0	3	3
2005	1	1	2
2006	2	4	6
2007	1	0	1
2008	2	3	5
2009	0	3	3
2010	1	3	4
2011	1	1	2
2012	2	3	5
2013	4	2	6
2014	0	1	1
2015	1	5	6
2016	0	2	2
2017	0	1	1
2018	0	2	2
2019	1	0	1
2020	2	0	2

Below are the most recent publications written about "Tumor Suppressor Protein p53" by people in Profiles.

Samsa WE, Mamidi MK, Bashur LA, Elliott R, Miron A, Chen Y, Lee B, Greenfield EM, Chan R, Danielpour D, Zhou G. The crucial p53-dependent oncogenic role of JAB1 in osteosarcoma in vivo. Oncogene. 2020 06; 39(23):4581-4591.

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Ramraj SK, Elayapillai SP, Pelikan RC, Zhao YD, Isingizwe ZR, Kennedy AL, Lightfoot SA, Benbrook DM. Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53. Int J Cancer. 2020 08 15; 147(4):1086-1097.

View in: PubMed
Delma CR, Thirugnanasambandan S, Srinivasan GP, Raviprakash N, Manna SK, Natarajan M, Aravindan N. Fucoidan from marine brown algae attenuates pancreatic cancer progression by regulating p53 - NF?B crosstalk. Phytochemistry. 2019 Nov; 167:112078.

View in: PubMed
Plafker KS, Zyla K, Berry W, Plafker SM. Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence. Redox Biol. 2018 07; 17:411-422.

View in: PubMed
Labgaa I, Villacorta-Martin C, D'Avola D, Craig AJ, von Felden J, Martins-Filho SN, Sia D, Stueck A, Ward SC, Fiel MI, Mahajan M, Tabrizian P, Thung SN, Ang C, Friedman SL, Llovet JM, Schwartz M, Villanueva A. A pilot study of ultra-deep targeted sequencing of plasma DNA identifies driver mutations in hepatocellular carcinoma. Oncogene. 2018 07; 37(27):3740-3752.

View in: PubMed
Cosgrove CM, Tritchler DL, Cohn DE, Mutch DG, Rush CM, Lankes HA, Creasman WT, Miller DS, Ramirez NC, Geller MA, Powell MA, Backes FJ, Landrum LM, Timmers C, Suarez AA, Zaino RJ, Pearl ML, DiSilvestro PA, Lele SB, Goodfellow PJ. An NRG Oncology/GOG study of molecular classification for risk prediction in endometrioid endometrial cancer. Gynecol Oncol. 2018 01; 148(1):174-180.

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Aravindan N, Aravindan S, Manickam K, Natarajan M. High Energy Particle Radiation-associated Oncogenic Transformation in Normal Mice: Insight into the Connection between Activation of Oncotargets and Oncogene Addiction. Sci Rep. 2016 11 23; 6:37623.

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Joneja U, Vranic S, Swensen J, Feldman R, Chen W, Kimbrough J, Xiao N, Reddy S, Palazzo J, Gatalica Z. Comprehensive profiling of metaplastic breast carcinomas reveals frequent overexpression of programmed death-ligand 1. J Clin Pathol. 2017 Mar; 70(3):255-259.

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Ang C, Miura JT, Gamblin TC, He R, Xiu J, Millis SZ, Gatalica Z, Reddy SK, Yee NS, Abou-Alfa GK. Comprehensive multiplatform biomarker analysis of 350 hepatocellular carcinomas identifies potential novel therapeutic options. J Surg Oncol. 2016 Jan; 113(1):55-61.

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Feldman R, Gatalica Z, Knezetic J, Reddy S, Nathan CA, Javadi N, Teknos T. Molecular profiling of head and neck squamous cell carcinoma. Head Neck. 2016 04; 38 Suppl 1:E1625-38.

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