Retinoblastoma Protein

"Retinoblastoma Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Product of the retinoblastoma tumor suppressor gene. It is a nuclear phosphoprotein hypothesized to normally act as an inhibitor of cell proliferation. Rb protein is absent in retinoblastoma cell lines. It also has been shown to form complexes with the adenovirus E1A protein, the SV40 T antigen, and the human papilloma virus E7 protein.

Descriptor ID	D016160
MeSH Number(s)	D12.776.260.704 D12.776.624.776.745 D12.776.660.807 D12.776.744.770
Concept/Terms	Retinoblastoma Protein Retinoblastoma Protein Rb1 Gene Product Rb Gene Product Rb Protein p105-Rb Protein p105-Rb Protein p105 Rb Protein Retinoblastoma Nuclear Phosphoprotein p105-Rb Retinoblastoma Nuclear Phosphoprotein p105 Rb

Below are MeSH descriptors whose meaning is more general than "Retinoblastoma Protein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
DNA-Binding Proteins [D12.776.260]
Retinoblastoma Protein [D12.776.260.704]
Neoplasm Proteins [D12.776.624]
Tumor Suppressor Proteins [D12.776.624.776]
Retinoblastoma Protein [D12.776.624.776.745]
Nuclear Proteins [D12.776.660]
Retinoblastoma Protein [D12.776.660.807]
Phosphoproteins [D12.776.744]
Retinoblastoma Protein [D12.776.744.770]

Below are MeSH descriptors whose meaning is related to "Retinoblastoma Protein".

Below are MeSH descriptors whose meaning is more specific than "Retinoblastoma Protein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Retinoblastoma Protein" by people in this website by year, and whether "Retinoblastoma Protein" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 3 publications in 2000

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	0	1
2000	3	0	3
2001	0	1	1
2008	1	0	1
2010	1	0	1
2011	1	0	1
2012	0	2	2

Below are the most recent publications written about "Retinoblastoma Protein" by people in Profiles.

Huddleston S, McNall-Knapp RY, Siatkowski M, Odom C, Brennan R, Wilson MW. A novel translocation t(11;13) (q21;q14.2) in a child with suprasellar primitive neuroectodermal tumor and retinoblastoma. Ophthalmic Genet. 2013 Mar-Jun; 34(1-2):97-100.

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Vuong L, Conley SM, Al-Ubaidi MR. Expression and role of p53 in the retina. Invest Ophthalmol Vis Sci. 2012 Mar 15; 53(3):1362-71.

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Park JK, Henry JC, Jiang J, Esau C, Gusev Y, Lerner MR, Postier RG, Brackett DJ, Schmittgen TD. miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011 Mar 25; 406(4):518-23.

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Wiedemeyer WR, Dunn IF, Quayle SN, Zhang J, Chheda MG, Dunn GP, Zhuang L, Rosenbluh J, Chen S, Xiao Y, Shapiro GI, Hahn WC, Chin L. Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11501-6.

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Lee J, Lu X, Shin ES, Kern WF, Mulvihill JJ, Li S. A novel subtelomeric translocation t(5;9) and a deletion of the RB1 gene in a patient with acute myeloid leukemia (AML-M0). Cancer Genet Cytogenet. 2008 Feb; 181(1):36-9.

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Hirschler-Laszkiewicz I, Cavanaugh A, Hu Q, Catania J, Avantaggiati ML, Rothblum LI. The role of acetylation in rDNA transcription. Nucleic Acids Res. 2001 Oct 15; 29(20):4114-24.

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Pelletier G, Stefanovsky VY, Faubladier M, Hirschler-Laszkiewicz I, Savard J, Rothblum LI, Côté J, Moss T. Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription. Mol Cell. 2000 Nov; 6(5):1059-66.

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Hannan KM, Hannan RD, Smith SD, Jefferson LS, Lun M, Rothblum LI. Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1. Oncogene. 2000 Oct 12; 19(43):4988-99.

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Hannan KM, Kennedy BK, Cavanaugh AH, Hannan RD, Hirschler-Laszkiewicz I, Jefferson LS, Rothblum LI. RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest. Oncogene. 2000 Jul 20; 19(31):3487-97.

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Cavanaugh AH, Hempel WM, Taylor LJ, Rogalsky V, Todorov G, Rothblum LI. Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product. Nature. 1995 Mar 09; 374(6518):177-80.

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