Structure-Activity Relationship

"Structure-Activity Relationship" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.

Descriptor ID	D013329
MeSH Number(s)	G02.111.830 G07.690.773.997
Concept/Terms	Structure-Activity Relationship Structure-Activity Relationship Relationship, Structure-Activity Relationships, Structure-Activity Structure Activity Relationship Structure-Activity Relationships

Below are MeSH descriptors whose meaning is more general than "Structure-Activity Relationship".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Structure-Activity Relationship [G02.111.830]
Physiological Phenomena [G07]
Pharmacological and Toxicological Phenomena [G07.690]
Pharmacological Phenomena [G07.690.773]
Structure-Activity Relationship [G07.690.773.997]

Below are MeSH descriptors whose meaning is related to "Structure-Activity Relationship".

Below are MeSH descriptors whose meaning is more specific than "Structure-Activity Relationship".

Structure-Activity Relationship
Quantitative Structure-Activity Relationship

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Structure-Activity Relationship" by people in this website by year, and whether "Structure-Activity Relationship" was a major or minor topic of these publications.

Bar chart showing 152 publications over 29 distinct years, with a maximum of 10 publications in 2009

To see the data from this visualization as text, click here.

Year	Minor Topic	Total
1992	1	1
1993	6	6
1994	2	2
1995	3	3
1996	2	2
1998	2	2
1999	8	8
2000	1	1
2001	2	2
2002	4	4
2003	8	8
2004	7	7
2005	5	5
2006	4	4
2007	7	7
2008	2	2
2009	10	10
2010	8	8
2011	5	5
2012	4	4
2013	6	6
2014	8	8
2015	6	6
2016	9	9
2017	6	6
2018	8	8
2019	8	8
2020	7	7
2021	3	3

Below are the most recent publications written about "Structure-Activity Relationship" by people in Profiles.

Pham OL, Feher SE, Nguyen QT, Papavassiliou DV. Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow. Sci Rep. 2022 01 07; 12(1):171.

View in: PubMed
Drumond-Bock AL, Bieniasz M. The role of distinct BRD4 isoforms and their contribution to high-grade serous ovarian carcinoma pathogenesis. Mol Cancer. 2021 11 10; 20(1):145.

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Islam F, Quadery TM, Bai R, Luckett-Chastain LR, Hamel E, Ihnat MA, Gangjee A. Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents. Bioorg Med Chem Lett. 2021 06 01; 41:127923.

View in: PubMed
Choudhary S, Doshi A, Luckett-Chastain L, Ihnat M, Hamel E, Mooberry SL, Gangjee A. Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer. Bioorg Med Chem. 2021 04 01; 35:116061.

View in: PubMed
Mehla J, Malloci G, Mansbach R, López CA, Tsivkovski R, Haynes K, Leus IV, Grindstaff SB, Cascella RH, D'Cunha N, Herndon L, Hengartner NW, Margiotta E, Atzori A, Vargiu AV, Manrique PD, Walker JK, Lomovskaya O, Ruggerone P, Gnanakaran S, Rybenkov VV, Zgurskaya HI. Predictive Rules of Efflux Inhibition and Avoidance in Pseudomonas aeruginosa. mBio. 2021 01 19; 12(1).

View in: PubMed
Dou X, Duerfeldt AS. Small-Molecule Modulation of PPARs for the Treatment of Prevalent Vascular Retinal Diseases. Int J Mol Sci. 2020 Dec 04; 21(23).

View in: PubMed
Xiang W, Quadery TM, Hamel E, Luckett-Chastain LR, Ihnat MA, Mooberry SL, Gangjee A. The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity. Bioorg Med Chem. 2021 01 01; 29:115887.

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Sundriyal S, Eeda V, Lagisetty P, Awasthi V. Tubulin inhibitory activity of a novel colchicine-binding compounds based on a dinaphthospiropyranran scaffold. Bioorg Med Chem. 2021 01 01; 29:115874.

View in: PubMed
Pederson PJ, Cai S, Carver C, Powell DR, Risinger AL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea. J Nat Prod. 2020 07 24; 83(7):2269-2280.

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Lam AK, Panlilio H, Pusavat J, Wouters CL, Moen EL, Brennan RE, Rice CV. Expanding the Spectrum of Antibiotics Capable of Killing Multidrug-Resistant Staphylococcus aureus and Pseudomonas aeruginosa. ChemMedChem. 2020 08 05; 15(15):1421-1428.

View in: PubMed

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