"Signal Transduction" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
| Descriptor ID |
D015398
|
| MeSH Number(s) |
G02.111.820 G04.835
|
| Concept/Terms |
Signal Transduction- Signal Transduction
- Signal Transductions
- Transduction, Signal
- Transductions, Signal
- Signal Transduction Systems
- Signal Transduction System
- System, Signal Transduction
- Systems, Signal Transduction
Signal Pathways- Signal Pathways
- Pathway, Signal
- Pathways, Signal
- Signal Pathway
Signal Transduction Pathways- Signal Transduction Pathways
- Pathway, Signal Transduction
- Pathways, Signal Transduction
- Signal Transduction Pathway
Receptor-Mediated Signal Transduction- Receptor-Mediated Signal Transduction
- Receptor-Mediated Signal Transductions
- Signal Transduction, Receptor-Mediated
- Signal Transductions, Receptor-Mediated
- Receptor Mediated Signal Transduction
|
Below are MeSH descriptors whose meaning is more general than "Signal Transduction".
Below are MeSH descriptors whose meaning is more specific than "Signal Transduction".
This graph shows the total number of publications written about "Signal Transduction" by people in this website by year, and whether "Signal Transduction" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 5 | 5 |
| 1994 | 0 | 4 | 4 |
| 1995 | 4 | 6 | 10 |
| 1996 | 6 | 9 | 15 |
| 1997 | 4 | 8 | 12 |
| 1998 | 4 | 5 | 9 |
| 1999 | 6 | 6 | 12 |
| 2000 | 6 | 8 | 14 |
| 2001 | 5 | 9 | 14 |
| 2002 | 8 | 11 | 19 |
| 2003 | 11 | 17 | 28 |
| 2004 | 8 | 15 | 23 |
| 2005 | 10 | 24 | 34 |
| 2006 | 8 | 17 | 25 |
| 2007 | 13 | 18 | 31 |
| 2008 | 16 | 29 | 45 |
| 2009 | 13 | 33 | 46 |
| 2010 | 5 | 27 | 32 |
| 2011 | 10 | 23 | 33 |
| 2012 | 15 | 32 | 47 |
| 2013 | 18 | 47 | 65 |
| 2014 | 15 | 33 | 48 |
| 2015 | 17 | 44 | 61 |
| 2016 | 7 | 32 | 39 |
| 2017 | 10 | 35 | 45 |
| 2018 | 6 | 27 | 33 |
| 2019 | 6 | 30 | 36 |
| 2020 | 10 | 34 | 44 |
| 2021 | 9 | 29 | 38 |
| 2022 | 1 | 7 | 8 |
| 2023 | 0 | 4 | 4 |
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click here.
Below are the most recent publications written about "Signal Transduction" by people in Profiles.
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cGMP Signaling in Photoreceptor Degeneration. Int J Mol Sci. 2023 Jul 07; 24(13).
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Single-molecule imaging in the primary cilium. Methods Cell Biol. 2023; 176:59-83.
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Insights of Endocytosis Signaling in Health and Disease. Int J Mol Sci. 2023 Feb 03; 24(3).
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Carbohydrate-Small Molecule Hybrids as Lead Compounds Targeting IL-6 Signaling. Molecules. 2023 Jan 09; 28(2).
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Analysis of CheW-like domains provides insights into organization of prokaryotic chemotaxis systems. Proteins. 2023 03; 91(3):315-329.
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Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism. Mol Cancer Res. 2022 09 02; 20(9):1391-1404.
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The emerging role of NOTCH3 receptor signalling in human lung diseases. Expert Rev Mol Med. 2022 09 02; 24:e33.
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Signaling by LncRNAs: Structure, Cellular Homeostasis, and Disease Pathology. Cells. 2022 08 13; 11(16).
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DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium. Proc Natl Acad Sci U S A. 2022 08 16; 119(33):e2207489119.
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Molecular basis for coordinating secondary metabolite production by bacterial and plant signaling molecules. J Biol Chem. 2022 06; 298(6):102027.