"Protein Binding" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
| Descriptor ID |
D011485
|
| MeSH Number(s) |
G02.111.679 G03.808
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Protein Binding".
Below are MeSH descriptors whose meaning is more specific than "Protein Binding".
This graph shows the total number of publications written about "Protein Binding" by people in this website by year, and whether "Protein Binding" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 4 | 4 |
| 1996 | 0 | 12 | 12 |
| 1997 | 0 | 8 | 8 |
| 1998 | 0 | 8 | 8 |
| 1999 | 0 | 12 | 12 |
| 2000 | 0 | 7 | 7 |
| 2001 | 0 | 13 | 13 |
| 2002 | 0 | 14 | 14 |
| 2003 | 0 | 27 | 27 |
| 2004 | 0 | 23 | 23 |
| 2005 | 0 | 18 | 18 |
| 2006 | 0 | 18 | 18 |
| 2007 | 0 | 18 | 18 |
| 2008 | 0 | 23 | 23 |
| 2009 | 0 | 31 | 31 |
| 2010 | 0 | 25 | 25 |
| 2011 | 0 | 24 | 24 |
| 2012 | 0 | 26 | 26 |
| 2013 | 0 | 22 | 22 |
| 2014 | 0 | 26 | 26 |
| 2015 | 0 | 22 | 22 |
| 2016 | 0 | 26 | 26 |
| 2017 | 0 | 17 | 17 |
| 2018 | 0 | 12 | 12 |
| 2019 | 0 | 9 | 9 |
| 2020 | 0 | 13 | 13 |
| 2021 | 0 | 17 | 17 |
| 2022 | 0 | 3 | 3 |
| 2023 | 0 | 1 | 1 |
| 2024 | 0 | 3 | 3 |
| 2025 | 0 | 2 | 2 |
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Below are the most recent publications written about "Protein Binding" by people in Profiles.
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Characterization of the Two-Domain Peptide Binding Mechanism of the Human CGRP Receptor for CGRP and the Ultrahigh Affinity ssCGRP Variant. Biochemistry. 2025 Apr 15; 64(8):1770-1787.
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Structure and unusual binding mechanism of the hyaluronan receptor LYVE-1 mediating leucocyte entry to lymphatics. Nat Commun. 2025 Mar 20; 16(1):2754.
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CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson's Disease Associated Protein. J Chem Inf Model. 2024 Nov 25; 64(22):8521-8536.
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Targeting HSP70-E7 Interaction With SHetA2: A Novel Therapeutic Strategy for Cervical Cancer. J Med Virol. 2024 Nov; 96(11):e70088.
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A conserved C-terminal domain of TamB interacts with multiple BamA POTRA domains in Borreliella burgdorferi. PLoS One. 2024; 19(8):e0304839.
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Structure-Activity Relationships of Ligand Binding to Oxysterol-Binding Protein (OSBP) and OSBP-Related Protein 4. J Med Chem. 2023 03 23; 66(6):3866-3875.
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Comprehensive characterization of the Hsp70 interactome reveals novel client proteins and interactions mediated by posttranslational modifications. PLoS Biol. 2022 10; 20(10):e3001839.
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Crystal structure of the middle and C-terminal domains of Hsp90a labeled with a coumarin derivative reveals a potential allosteric binding site as a drug target. Acta Crystallogr D Struct Biol. 2022 May 01; 78(Pt 5):571-585.
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Accurate MHC Motif Deconvolution of Immunopeptidomics Data Reveals a Significant Contribution of DRB3, 4 and 5 to the Total DR Immunopeptidome. Front Immunol. 2022; 13:835454.
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ParD Antitoxin Hotspot Alters a Disorder-to-Order Transition upon Binding to Its Cognate ParE Toxin, Lessening Its Interaction Affinity and Increasing Its Protease Degradation Kinetics. Biochemistry. 2022 01 04; 61(1):34-45.