DNA Cleavage

"DNA Cleavage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A reaction that severs one of the covalent sugar-phosphate linkages between NUCLEOTIDES that compose the sugar phosphate backbone of DNA. It is catalyzed enzymatically, chemically or by radiation. Cleavage may be exonucleolytic - removing the end nucleotide, or endonucleolytic - splitting the strand in two.

Descriptor ID	D053837
MeSH Number(s)	G02.111.210 G05.193
Concept/Terms	DNA Cleavage DNA Cleavage

Below are MeSH descriptors whose meaning is more general than "DNA Cleavage".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
DNA Cleavage [G02.111.210]
Genetic Phenomena [G05]
DNA Cleavage [G05.193]

Below are MeSH descriptors whose meaning is related to "DNA Cleavage".

Below are MeSH descriptors whose meaning is more specific than "DNA Cleavage".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "DNA Cleavage" by people in this website by year, and whether "DNA Cleavage" was a major or minor topic of these publications.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2008 and 2009 and 2011 and 2016 and 2017 and 2019 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2008	0	1	1
2009	1	0	1
2011	0	1	1
2016	0	1	1
2017	1	0	1
2019	0	1	1
2021	0	1	1

Below are the most recent publications written about "DNA Cleavage" by people in Profiles.

Zuo Z, Babu K, Ganguly C, Zolekar A, Newsom S, Rajan R, Wang YC, Liu J. Rational Engineering of CRISPR-Cas9 Nuclease to Attenuate Position-Dependent Off-Target Effects. CRISPR J. 2022 04; 5(2):329-340.

View in: PubMed
Babu K, Kathiresan V, Kumari P, Newsom S, Parameshwaran HP, Chen X, Liu J, Qin PZ, Rajan R. Coordinated Actions of Cas9 HNH and RuvC Nuclease Domains Are Regulated by the Bridge Helix and the Target DNA Sequence. Biochemistry. 2021 12 14; 60(49):3783-3800.

View in: PubMed
Parameshwaran HP, Babu K, Tran C, Guan K, Allen A, Kathiresan V, Qin PZ, Rajan R. The bridge helix of Cas12a imparts selectivity in cis-DNA cleavage and regulates trans-DNA cleavage. FEBS Lett. 2021 04; 595(7):892-912.

View in: PubMed
Babu K, Amrani N, Jiang W, Yogesha SD, Nguyen R, Qin PZ, Rajan R. Bridge Helix of Cas9 Modulates Target DNA Cleavage and Mismatch Tolerance. Biochemistry. 2019 04 09; 58(14):1905-1917.

View in: PubMed
Sundaresan R, Parameshwaran HP, Yogesha SD, Keilbarth MW, Rajan R. RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a. Cell Rep. 2017 12 26; 21(13):3728-3739.

View in: PubMed
Rodgers KK. Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures. Trends Biochem Sci. 2017 01; 42(1):72-84.

View in: PubMed
Goff RD, Singh S, Thorson JS. Glycosyloxyamine neoglycosylation: a model study using calicheamicin. ChemMedChem. 2011 May 02; 6(5):774-6.

View in: PubMed
Gwyn LM, Peak MM, De P, Rahman NS, Rodgers KK. A zinc site in the C-terminal domain of RAG1 is essential for DNA cleavage activity. J Mol Biol. 2009 Jul 31; 390(5):863-78.

View in: PubMed
De P, Zhao S, Gwyn LM, Godderz LJ, Peak MM, Rodgers KK. Thermal dependency of RAG1 self-association properties. BMC Biochem. 2008 Jan 30; 9:5.

View in: PubMed

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